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The Pandemic COVID-19 and Molecular Basis of SARS-CoV-2 Infection The pandemic COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus has dramatically affected human life and the world economy with more than 178 million confirmed cases and 3.8 million deaths (June 2021, WHO COVID-19 dashboard)

Known genetic biomarkers of changes in VPA metabolism are summarized by us and presented in Appendix A

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In both groups, 56.7% of patients lost at least 5% of baseline weight

Genome-wide association analyses have detected critical polymorphisms in genes regulating hepatic lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), which promote intrahepatic triglyceride accumulation by impairing lipid remodeling or very-low-density lipoprotein (VLDL) secretion [16,17]