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Older adults, in particular, may require higher amounts due to absorption challenges or medications that interfere with vitamin absorption
63 (22), e1900492
The magnitude varies based on lifestyle factors and individual biology
Individuals dealing with burnout, persistent fatigue, or systemic inflammation who may benefit from better NAD+ preservation and mitochondrial support
Those who've had certain surgeries: Gastrointestinal surgeries may reduce intrinsic factor production, limiting B12 uptake from food or oral supplements
Whether this reflects genuine cardiovascular benefit or simply the healing of minor injuries that were limiting exercise capacity remains unclear
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