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As of this review, only one large randomized clinical trial of semaglutide in youth has been completed, with a follow-up duration of 68 weeks [54]
doi:10.1001/jamanetworkopen.2024.57349 NICE (2025) Quality statement 7: Advice and support after stopping medicines for weight management or completing behavioural interventions (Accessed: 10 August 2025)
Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or dehydration risk, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, any personal or family history of medullary thyroid carcinoma or MEN2, and a history of diabetic retinopathy
Again, keep in mind that nausea tends to occur early in the process
Tirzepatide, the active ingredient in Zepbound, mimics GLP-1 and GIP
This is when most patients commit fully to completing the 48-week course, having proof they can tolerate it and seeing meaningful results on the scale
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