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It has been described as generalized colonic dysfunction manifesting as severe colonic dilation and fecal impaction, or a severely and irreversibly dilated and hypomotile colon 140 and a subjective evaluation of the diameter of the colon, usually based on radiographic assessment. 18 There are specific radiographic guidelines for humans with megacolon, in that a colonic diameter of more than 6.5 cm at the level of the pelvic brim is considered diagnostic

Transl Psychiatr 2021;11:23

M., Sanders L., et al

[2] It is important to note that whilst fatigue and general malaise may improve relatively quickly, complete symptom resolution requires adequate time for the body to replenish B12 stores and repair affected tissues

This highlights the necessity for further research into the microbiome-gut-brain axis to fully understand its role and implications [38]

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