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In metabolic diseases such as diabetes, co-delivery systems integrating GLP-1RAs with complementary agents such as DPP-4 inhibitors or insulin have demonstrated superior long-term glycemic control compared to monotherapies

Current data suggests that the relevance of targeting MC1R mediated pathways may depend on receptor expression levels and genetic background, emphasizing the need for continued research to clarify the receptors protective roles within epidermal layer biology

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Prieto-Hontoria PL, Prez-Matute P, Fernndez-Galilea M, Martnez JA, Moreno-Aliaga MJ