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ERK1/2 activation in endothelial cells with upregulation of c-Fos, c-Jun, and Egr-1, regulating cell proliferation and vascular tube formation in vitro
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The development cost of $150-250 million represents a 20-30x ROI at those volumes, before accounting for litigation risk and settlement delays
van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al
After 50 days of continuous administration followed by 14 days of drug withdrawal, the total sperm motility of mice was almost 0, and a large number of abnormal eosinophilic spermatogenic cells appeared in the testis
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