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The key difference between sciatica pain and other low back conditions is that you feel the pain only in one leg, hip, or side of your buttocks

| 2017 | International Journal of Molecular Sciences 21Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection

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For example, TREM2 inhibits STAT3 phosphorylation by activating the tyrosine phosphatase SHP1, thereby alleviating oxidative stress and ferroptosis and significantly mitigating S-ALI (Wu et al., 2025)

3.2.1 C-reactive protein (CRP) CRP is a classic acute-phase protein synthesized by the liver under the stimulation of pro-inflammatory cytokines like IL-6, and it serves as the gold standard for measuring acute inflammation and tissue injury (86)