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This results in reduced appetite and enhanced insulin secretion, leading to improved blood sugar control

Stephens, M

Further, it positively impacts bone health and prevents age-related cognitive decline

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Finally, GR SUMOylation at Lys277, Lys293, and Lys703 has been shown to decrease protein stability, DNA binding ability, and transcriptional activity, leading to decreased GR function ( 2.3 Glucocorticoid receptor physiology: molecular mechanisms of action 2.3.1 Genomic mechanisms of action GR is localized in the nucleus, cytosol, mitochondria, and cell membrane ( Figure 2 )

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