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A nested case-control study within the Singapore Chinese Health Study demonstrated a significant 57% reduction in colon cancer risk among high consumers of dietary isothiocyanates (ITCs) who carried the double null genotype, suggesting that compromised GST activity enhances the protective effect of ITCs like SFN (59)

[DOI] [PubMed] [Google Scholar] 104.Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, et al

10.1016/j.ejphar.2023.175716 261 ZhangQ.SunQ.TongY.BiX.ChenL.LuJ.et al (2022b)

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Modifying factors [edit] Enzyme induction and inhibition [edit] The duration and intensity of pharmacological action of most lipophilic drugs are determined by the rate they are metabolized to inactive products