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Their hydrophilicity prevents efficient transcellular transport (crossing through cell membranes), while their size prevents efficient paracellular transport (passing between cells)

When concentrations are in the range between four times and one fourth of the C 50 , the time course of effect is essentially a linear function of time

Specifically, the cytokine TGF- hinders the production of GSH, causing a chain reaction: lower GSH results in heightened free radicals, exacerbated by an increase in proinflammatory cytokines

Inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase

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