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In line with this hypothesis, a knock-in mice, expressing a MOR chimera where the C-terminus tail was replaced by the C-terminus tail of DOR, demonstrated less tolerance after chronic morphine treatment (Kim et al., 2008), correlated to a decrease of tolerance biomarkers (He et al., 2009)

Increased ROS caused by ultraviolet radiation leads to DNA damage and cellular dysfunction [298]

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Clinical evidence shows hypertensive patients without diabetes experience similar or greater blood pressure reductions as those with type 2 diabetes

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