In addition, Pycnogenol increased the total antioxidant status (TAS) and improved the glutathione levels, another index for antioxidant capacity in the children with ADHD ( administration, while reduced glutathione (GSH) was significantly increased by 26.8% after one month and by 36.4% after 2 months compared to baseline ( s effects on ADHD symptoms by improving the antioxidant status
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However, it is worth noting that most preclinical studies do not incorporate a dose titration phase, a gradual increase to the therapeutic maintenance dose, which is standard in clinical settings
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