Uric Acid Disturbance: Emphasis on Purines Monosodium urate crystals formation occurs when the urate concentrations continue to rise beyond the point required for spontaneous generation (nucleation)
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269,270 An imbalance between mitochondrial biogenesis and fission leads to the formation of small, dysfunctional mitochondria, affecting both neurons and Schwann cells and exacerbating peripheral nerve damage
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