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Moreover, since the drugs rate of dissociation from its protein-binding partner is determined by the proteins affinity for the drug of choice, it may, one day, be possible to modify the specific site of the protein so that the drug would be released at a predetermined rate, maintaining the proper concentration of free drug in the bloodstream

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doi: 10.1016/S1043-9471(05)80049-7 4 BarlierA.ZamoraA