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lactis HN019 alone, at a dose of 10 billion CFUs per day, for 28 days increased stool frequency and reduced straining in a subgroup of those reporting three or fewer bowel movements per week at baseline (Ibarra 2018)

I'm just using that as a metaphor

Association between chronic tinnitus and brain-derived neurotrophic factor antisense RNA polymorphisms linked to the Val66Met polymorphism in BDNF

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Research studies have generally looked at outcomes over 412 weeks, which aligns with this timeline