Retatrutide has shown some of the highest weight loss percentages in early research among injectable treatments
Glucose, insulin, and PTTs Male C57BL/6J, Glp1r KO, and db/db mice were fasted overnight (18:00 to next 10:00) or for 4 h (9:0013:00) in GTT, for 4 h in ITT, and overnight in PTT
As a result of rapid weight loss, the face can begin to hollow and look deflated
Then patients receive an at-home metabolic test that they complete and mail back to Ro's lab for processing (measuring A1C, cholesterol, thyroid, and kidney health)
A 72-week, double-blind phase 2 trial showed that once-daily administration of semaglutide had a significant therapeutic effect on NASH (193)
And so this is where I argue that we need to be looking at things a bit more preventatively and intervening