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Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS (Mari et al., 2010)

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Because it binds less tightly to IGF-binding proteins and circulates longer, IGF-1 LR3 produces a more sustained activation of IGF-1 receptors in vitro and in animal studies

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