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Consistently, the predicted pose of the hit engages a comparable set of residues, suggesting partial overlap in receptor engagement despite differences in chemical scaffold

We describe a comprehensive multidisciplinary approach leading to the development of MEDI7219, a GLP-1 receptor agonist (GLP-1RA) specifically engineered for oral delivery

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This article reviews the mechanisms by which SIRT1 intervenes in the progression of MAFLD: 1) promoting autophagy and enhancing mitochondrial function