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Funding This work was supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0506705), National Science and Technology Major Project (2023YFC3502601), Henan Province Science and Technology Innovation Leading Talent Support Project (254200510041), Henan Provincial Science and Technology Research and Development Plan Joint Fund (Advantageous Discipline Cultivation Category) Project (232301420088)