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Furthermore, these drugs are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Pattern HED extrapolation ceiling Daily Dose ~650 mg/day Tablet Math (50 mg) 13 tablets/day included only to show the gap with vendor doses Frequency n/a Notes Allometric scaling from 100 mg/kg/day mouse dose to 80 kg human

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Human biospecimens, clinical data and metabolite analysis of human samples Human biospecimens and deidentified clinical data were provided by the Wilmot Cancer Institute Biobank Shared Resource (BSR) at the University of Rochester

doi: 10.3945/ajcn.112.052746 224