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Patch test first and stop use if irritation continues

usually comprises melanocytes Melanocytes Mammalian pigment cells that produce melanins, pigments found mainly in the epidermis, but also in the eyes and the hair, by a process called melanogenesis

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However, the cardiovascular outcome trials that have been completed so far have failed to show cardioprotection with DPP-4 inhibitor treatment, which might be partly attributable to limitations of the study design, patient selection and trial duration