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Overall, in both analyses, the risk of developing neovascular age-related macular degeneration while taking semaglutide or the other study medications for type 2 diabetes did not differ enough to be considered greater or less than random chance, the researchers concluded

Retatrutide activates 3 receptors (GLP-1, GIP, glucagon) to reduce appetite, improve metabolism, and burn fat

Diarrhea, constipation, and decreased appetite (which is both a side effect and the intended mechanism) round out the most common complaints

To minimize gastrointestinal symptoms, eat smaller, more frequent meals rather than large portions

Greater total weight loss in the triplet group (13.2% vs 10.4%)

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