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Melatonin, a hormone produced mainly by the brains pineal gland, may play a role in the increased risk of psoriasis associated with sleep disruption

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"Coming in, waking them up a little bit, like giving them a hug or something like that in a comforting way, and putting them back to sleep almost like, resets the body's sleep cycle, so that REM experience doesn't come on in a more extreme way

10.1038/nn.3109 Nat