They found that the infection itself caused a depletion in glutathione, and that the immune cells, in turn, could not control the mycobacteria
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It does not shut off the immune system
fumigatus is the strong ZafA-mediated induction of the genes gliA , gliT , gliZ , and gtmA (Vicentefranqueira et al., 2018) that are involved in the biosynthesis and regulation of, and tolerance to, gliotoxin (Dolan et al., 2015)
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In contrast to pro-inflammatory microglial activation, M2 microglia activation increases anti-inflammatory cytokine production, promoting neuroprotection through tissue repair and debris clearance