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Experiments in mice with Sm-TSP-2 encoding EC2 or Sm-TSP-2/5B chimera (hookworm vaccine candidate) co-administered with CpG/alum reduced worm burden by 25-27% and 54-58%, and liver eggs by 20-27% and 48-56%, respectively, and induced higher titers of total IgG, IgG1 and IgG2 antibodies in the Sm-TSP-2/5B group (65, 69)
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