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The random sampling of sections for stereological charting of cardiac fibrosis is often not suitable as the fibrosis is not uniformly distributed in the myocardium, whereas analysis of specific planes may not capture the stochastically developing fibrosis (Schipke et al., 2017)

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During times of prolonged stress glutathione levels rapidly reduce as do our natural defences towards inflammation, invaders, bacteria, and viruses

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