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[31] [32] In the United States, for instance, the prevalence of MIBP detection in urine has risen from 72% of the general population in 20012002 to 96% in 20092010, according to data from the National Health and Nutrition Examination Survey (NHANES)

& Mieyal, J

P., Schwerdtle, T., & Bornhorst, J

These engineered drug delivery systems significantly enhance therapeutic outcomes in gout and hyperuricemia by improving drug solubility, enabling targeted delivery, providing sustained release, facilitating synergistic drug co-delivery, and responding to pathological microenvironments, although preclinical evidence is limited and clinical evidence supporting their efficacy and safety remains sparse