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While GLP-1 medications improve glycemic control in patients with type 2 diabetes, lower blood glucose levelsparticularly if they drop too quicklycan sometimes be associated with feeling cold

This overlap creates challenges in distinguishing medication effects from disease flares

Glial cells

The problem is that natural GLP-1 gets broken down within minutes by an enzyme called DPP-4

It includes the FDA-approved active salt, Semaglutide base (1.34 mg/ml), a Glucagon-like Peptide-1 (GLP-1) receptor agonist

For instance, researchers can perform mass spectrometry on the pulled-down proteins to identify their identities and post-translational modifications