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The research connects to broader literatures on copper-dependent enzymes and on extracellular matrix biology in development, aging, and tissue disease

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A Johns Hopkins study published last winter found that in 2020, for 135 top-selling prescription drugs, the median promotional spending per drug was $20.9 million

The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]