50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering
Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations
Whole-cell patch-clamp recordings were performed on mRFP--actin-transfected hippocampal neurons to measure miniature excitatory postsynaptic currents (mEPSCs), reflecting synaptic activity [2]
Research focus areas include: Neurogenesis and synaptogenic mechanisms Cognitive function and memory consolidation pathways Neuroprotection in models of brain injury and neurodegeneration Potentiation of HGF/c-Met signaling cascades Product Specifications Peptide content per capsule : 10 mg DIHEXA Capsule count : 30 Form: Stable research capsules optimized for compound integrity Purity : 99% (verified by independent third-party HPLC and mass spectrometry) Appearance : White to off-white powder encapsulated in size 0 vegetarian capsules Storage : Cool, dry place
Overall loss of muscle mass ranged from 32-45% and none of the 10 experimental treatment groups experienced any significant changes in muscle mass when administered treatment
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision
