The way you get that B-12 matters just as much as how much you take
80 So, while the results sound good, we have to view them as very low-quality evidence
We strongly advise patients to exercise caution and consult with our experienced healthcare professionals before considering any unapproved substances or therapies
Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors
Cyano-B12 is the most commonly used, and cheapest, form of B12 with no substantial evidence that other forms are more effective in improving B12 status
Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis
