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However, they will not automatically move into Category 1, where the agency has stated it would generally not take action against compounders

Copper accumulation is unlikely at standard research doses

The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

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Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted

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