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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene targeted by GLP-1 signaling), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) map the metabolic terrain the compound acts on

Samples were stored at 80 o C until sectioned (10 m)

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Understanding each drug's mechanism helps explain why combining them remains largely experimental and requires physician discretion

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