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The transition toward oral delivery will be evolutionary, not disruptive, dependent on regulatory approvals, proven equivalence in cardiovascular outcomes, and competitive pricing

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Overall, while these independent studies suggest that gut-derived GLP-1 minimally contributes to beta-cell GLP-1R stimulation, a fundamental limitation to these interpretations is that these studies do not specifically manipulate alpha-cell GLP-1, as these models are deficient in all proglucagon-derived peptides