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SURMOUNT-5, published in the New England Journal of Medicine, directly compared the maximum tolerated doses of tirzepatide and semaglutide in the same patient population

1 Within the past decade, longer-acting GLP-1 RA formulations entered the market as once-weekly, self-administered injectable pens most notably, semaglutide

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Then switch to as needed only

"Food stays in your stomach for longer than usual, satiating your hunger but leading to bacterial overgrowth," he explained, adding that these bacteria "ferment" the food and produce gas