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The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions

\n\n\n\n It is critical to note, however, that preclinical safety data no matter how consistently positive cannot be directly extrapolated to humans without proper clinical trials

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Acute dosing studies show immediate enzyme inhibition, but chronic metabolic remodelling follows a slower timeline that matches adipocyte turnover rates

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I have gout, and there can be a flare-ups almost daily, especially during and after work