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the KYDN neurons and then GnRH-secreting neurons) (25), the positive improvement of the metabolic impairment is probably not the only one needed to re-activate a normal reproductive profile, given that no significant changes in plasma LH concentrations were observed during the 6 months of treatment

Front Neuroendocrinol (2022) 64:100952

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Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by Urolithin A attenuates D-galactose-induced brain aging in mice

The somatostatin analogue franchise Sandostatin (octreotide) and Signifor (pasireotide) represents an established peptide therapy presence in the neuroendocrine tumour and Cushing's disease markets

Side Effect Profiles Both medications, sharing a foundational ingredient, have overlapping side effect profiles, including nausea, diarrhoea, and abdominal pain