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Among them, enhanced metabolic detoxification and target site insensitivity are the most common mechanisms [5, 33-35]

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These enhancements included the addition of a covalent tether to create a bicyclic peptide, removal of two unnecessary amino acids at positions 9 and 10, and incorporation of phosphotyrosine mimetics

TB-500's active sequence (LKKTETQ) binds G-actin, reduces inflammation, and mobilizes progenitor cells from bone marrow to injured tissue

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