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Response: We appreciate commenters' recommendation to assign more weight to numerator component (3)
Large-scale randomised controlled trials, including the STEP 1 trial (Wilding et al., NEJM 2021) for semaglutide 2.4 mg, have demonstrated clinically meaningful and sustained weight loss in adults with obesity or overweight with weight-related comorbidities
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Another common thiamin deficiency known as Wernicke-Korsakoff syndrome can cause similar symptoms as beriberi, such as confusion, loss of coordination, vision changes, hallucinations, and may progress to coma and death