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Despite these encouraging findings, substantial heterogeneity across published studies precludes definitive conclusions regarding the therapeutic efficacy of probiotics in obesity and cardiometabolic management

These have no FDA-approved drug status, no Phase III trial data supporting their use in humans, and no established dosing standards for clinical practice

Acknowledgements We thank the nference engineering team for the development of the nSights federated AI platform, and Patrick Lenehan and Christopher Gregg for critical review and feedback.

Whether the emptying effect differs meaningfully for solid mixed meals versus caloric liquids, which affects real-world relevance

Potential studies in non-English were translated with the aid of translation software or translators, if necessary