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Another reason behind this divergence in findings could be, along with the common use of unmetabolized (poly)phenols, the high and non-physiologically relevant doses employed in these in vitro studies, which can be up to 100 thousand times higher than biological plasma concentrations (Reference Manach, Scalbert and Morand17)

doi: 10.1097/MOL.0b013e32832d3b9d 101

Anti-inflammatory Action Downregulates TNF-alpha and IL-6 inflammatory markers

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(Hear Kimberly Ferrero discuss the article and more in a podcast episode of Actuary Voices )