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Propiedades antifibrticas y remodelantes de tejidos : Las investigaciones han demostrado que GHK-Cu reduce la fibrosis en modelos de hgado, pulmn y piel al inhibir el TGF-1 y otros genes profibrticos

Copper-deficient rat embryos are characterized by low superoxide dismutase activity and elevated superoxide anions

In apoptosis, -sitosterol upregulates pro-apoptotic factors such as p53 and Bax, while downregulating anti-apoptotic proteins such as Bcl-2, leading to an increase in mitochondrial outer membrane permeability and the activation of key apoptotic enzyme cascades such as caspase-9 and 3, which induces programmed cell death (83)

Funding The author(s) declared that financial support was received for this work and/or its publication

Bioactive tripeptides such as GHK-Cu and Lysine-Proline-Valine (KPV), including advanced formulations like KPV incorporated into in situ mucoadhesive hydrogels (KPV@PPP_E), can influence key biological events

The frequency sweep results, as illustrated in Fig