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Lee et al., 2022

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161 Overactivation of ionotropic receptors as well as mechanoporation of cellular membranes 162 lead to a massive Ca 2+ entry that mediates cellular death

These changes cannot occur without reducing the central cobalt ion from the + 3 oxidation state to + 2 or + 1 because cobalamins with a Co + 3 central ion are stable six-coordinate systems

Avoid using pill organizers for long-term storage unless the contents will be used within a week, as they may expose supplements to air and light more frequently