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Novo Nordisk has filed CagriSema with the FDA for a weight-loss indication based on earlier REDEFINE program data

Women who conceived within six months of starting GLP-1 RAs were twice as likely to have polycystic ovary syndrome compared to those who did not

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From a methodological perspective, the included studies provide complementary evidence across different designs

However, this does not now apply to all regions: in middle-income countries, agriculture is increasingly mechanized, cars are used for transport, and homes are supplied with water and domestic fuels (91)