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In a rat model of focal cerebral ischemia, 3-AB reduced lesion volumes and attenuated NMDA-induced neurotransmitter dysregulation 173

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This is consistent with our results showing that (i) the expression of Mck1p, the yeast homolog of GSK3, antagonizes the effect of CYS4 -OE in yeast (Figures 2AB) and (ii) the expression of a constitutively active form of GSK3 decreased H 2 S production in HepG2 cells (Figure 2G)

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