Owing to the unabsorbed fat in the intestine, orlistat causes some side effects, among which the most common are diarrhea, flatulence, bloating, abdominal pain, and dyspepsia [38]
Without adequate intrinsic factor, only approximately 1% of dietary B12 can be absorbed through passive diffusion , compared to the normal active transport mechanism which is far more efficient
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Vitamin B12 in health and disease
[1] Unlike NAD+ building blocks (NMN, NR), it targets the enzyme bottleneck itself instead of adding more raw material