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Conversely, while inflammatory mediators can induce metabolic reprogramming, the fundamental driver of persistent inflammation lies in metabolic reprogrammingwith metabolites such as lactate sustaining and amplifying inflammatory states to form a pathological loop (112, 113)

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Ccl2 forward: 5-TTA AAA ACC TGG ATC GGA ACC AA-3 and reverse, 5-GCA TTA GCT TCA GAT TTA CGG GT-3

Glucose uptake was assessed using 2-NBDG (Thermo Fisher Scientific) at a final concentration of 100 M for 1 hour

Stable for up to 60 days when using bacteriostatic water [9]