(One honest caveat: a nanomolar concentration in a lab dish is not the same unit as a topical percentage on skin we cite this to show the molecule is potent at low levels, not to claim 0.10% equals that figure.) Copper is potent, and potency cuts both ways
Severe glutathione depletion permits these intermediates to damage hepatocytes
Banerjee, R
Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, et al
Initially, excitotoxicity can be effectively mitigated, yet with the passage of time, its deleterious influence progressively intensifies, culminating in the intractability of neurodegenerative diseases
10.1530/REP-09-0054 Reproduction 114 MollR.LevyR.CzernobilskyB.HohlwegmajertP.DallenbachhellwegG.FrankeW