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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation
In: Methods in enzymology
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10 In humans, oral doses of GSH 15 mg/kg increased plasma GSH 1.5- to 10-fold over the basal concentration in 4 of 5 volunteers tested
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