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Gender-based considerations The phase 2 trial included both men and women, and the results did not show statistically significant differences in weight loss between genders at matched doses

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3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes

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